LABORATORY-DEVELOPED SIMULATED MOVING BED FOR CHIRAL DRUG SEPARATIONS - DESIGN OF THE SYSTEM AND SEPARATION OF TRAMADOL ENANTIOMERS

摘要

The design of a laboratory-developed simulated moving bed (SMB) is described. The main features of the system are outlined. The efficiency of the SMB to resolve chiral drugs is illustrated by the separation of Tramadol enantiomers at various feed concentrations. Advantages over preparative batch chromatography in terms of solvent and chiral phase consumption are demonstrated.