ALTERNATIVE METHODS FOR THE DETERMINATION OF TRACE AMOUNTS OF 4-AMINOMORPHOLINE IN MOLSIDOMINE AND LINSIDOMINE

摘要

Different methods based on either ion chromatography with electrochemical detection or precolumn derivatization with o-phthaldialdehyde were developed to determine trace amounts of 4-aminomorpholine in molsidomine and linsidomine. Electrochemical detection combined with ion chromatographic separation revealed outstanding selectivity whereas derivatization with o-phthaldialdehyde turned out to be very sensitive using RP-HPLC and standard UV detection. [References: 6]