HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC SEPARATION OF BETA-AMINO ALCOHOLS .2. SEPARATION OF TRANS-2-(DIALKYLAMINO)CYCLOHEXANOLS ON AN AMYLOSE-BASED CHIRAL STATIONARY PHASE

摘要

Direct enantiomeric separations of racemic mixtures of trans-2-(dialkylamino) cyclohexanols were achieved with a variety of alcohol-modified pentane mobile phases and a Chiralpak AD chiral stationary phase. The effects of the aliphatic component and the alcohol modifier in the mobile phase were studied independently. A variety of alcohol modifiers were investigated that introduced steric factors or affected hydrogen bonding. Ring-size effects of the substituents were noted.