SEPARATION AND SIMULTANEOUS DETERMINATION OF THE COMPONENTS IN AN ANALGESIC TABLET FORMULATION BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY

摘要

The separation and simultaneous determination of the active ingredients of an analgesic tablet formulation composed of caffeine, paracetamol, dextropropoxyphene, acetylsalicylic acid and chlorpheniramine was investigated by micellar electrokinetic chromatography (MEKC). As the use of sodium dodecyl sulphate could not resolve the two basic compounds, the separation was completed by using a mixture of the bile salts sodium cholate and sodium deoxycholate. The determination of the five ingredients together with salicyclic acid could be performed with acceptable accuracy and precision. [References: 20]