ANALYSIS OF IRRITANTS BY CAPILLARY COLUMN GAS CHROMATOGRAPHY TANDEM MASS SPECTROMETRY

摘要

Daughter spectra were obtained for the molecular and principal electron impact fragmentation ions of four irritants, 1-methoxycycloheptatriene, 2-chloroacetophenone, o-chlorobenzylidenemalononitrile and dibenz[b,f]-1,4-oxazepin, during capillary column GC-MS/MS analysis. The use of standardized collisional activated dissociation cell conditions resulted in the acquisition of daughter spectra suitable for identification and data-base generation purposes. Daughter operation detection limits of 100 pg (S/N > 10:1), for the highest molecular mass irritant, dibenz[b,f]-1,4-oxazepin, were obtained. This level of sensitivity was approximately the same as that routinely obtained for chemical warfare agents during capillary column GC-MS analysis under electron impact ionization conditions. The specificity of GC-MS/MS was demonstrated by spiking a complex diesel exhaust extract, with 1-methoxycycloheptatriene. [References: 21]