Improved method for the determination of zinc pyrithione in environmental water samples incorporating on-line extraction and preconcentration coupled with liquid chromatography atmospheric pressure chemical ionisation mass spectrometry

摘要

A method has been developed for the determination of zinc pyrithione (ZnPT) in environmental water samples using monolithic reversed-phase silica columns for rapid on-line large volume solid phase extraction in tandem with on-line matrix removal using sacrificial strong anion exchange (SAX) columns. This is coupled with reversed-phase liquid chromatography with atmospheric pressure chemical ionisation mass spectrometric detection. Limits of detection in spiked river water samples, using a 200 mL preconcentration volume, were determined as 18 ng L-1, with a limit of quantitation of 62 ng L-1. The percentage recovery from spiked river water was found to be 72 +/- 9 (n = 3 extractions), whilst overall method precision, following 10 repeat complete analyses was found to be 27% RSD at I jig L-1. Linearity was determined over the concentration range of 0.25- 10 mu g L-1 and the calculated regression coefficient was R-2 = 0.9802. The method was used to investigate the environmental fate of zinc pyrithione in waters and its partition coefficient between sediment and water phases. (c) 2006 Elsevier B.V. All rights reserved.