DIRECT SEPARATION OF CARBOXYLIC ACID AND AMINE ENANTIOMERS BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ON REVERSED-PHASE SILICA GELS COATED WITH CHIRAL COPPER(II) COMPLEXES

摘要

Excellent direct separation of various carboxylic acid and amine enantiomers was accomplished by HPLC on reversed-phase silica gels coated with copper(II) complexes of N,S-dioctyl-D-penicillamine and (R,R)-tartaric acid mono-(R)-1-(alpha-naphthyl)ethylamide. The chiral recognition mechanism is discussed. These copper(II) complexes are promising as chiral stationary phases for the separation of a variety of racemic carboxylic acids and amines in which copper(II) complex formation can be assumed. [References: 8]