Study of Surrogates for SW846 Method 8330

摘要

The compounds 1, 4-dinitrobenzene (1, 4-DNB), 1, 2-dinitrobenzene (1, 2-DNB), and 3, 4-dinitrotoluene are investigated as possible surrogate compounds. Both 1, 4-DNB and 1, 2-DNB do not coelute with any method target compounds in a C8 column with the specification of 82 precent water and 18 precent isopropanol at 1.0 mL/min. Elution conditions using a cyanopropyl (LC-CN) confirmation column are studied for the separation of target analytes and the surrogate compound. Adequate separation on a LC-CN column can also be achieved for the 1, 4-DNB and method target analytes using an eluent composed of 55 precent water, 40 precent methanol, and 5 precent acetonitrile at 1.2 mL/min. 1, 4-DNB is suitable for use as a surrogate in the Environmental Protection Agency Solid Waste 846 Method 8330. It is shown that utilization of 1, 4-DNB as a surrogate compound in Method 8330 analysis improves the defensibility of the data.