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首页> 外文期刊>Journal of clinical biochemistry and nutrition. >Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese
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Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese

机译:健康日本人中铜蓝蛋白和包括铁蛋白在内的氧化生物标志物的关系

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Serum ceruloplasmin (CP), a marker relevant to copper metabolism, is one of famous inflammation markers with a reduction in Wilson's disease, whereas serum ferritin is a marker relevant to iron metabolism. Recently, ferritin is pointed out to be related with oxidative stress. However, there is still no population research which showed the relation of CP and ferritin. Therefore, we investigated the relationship between CP and ferritin including oxidative stress biomarkers among healthy Japanese (n = 389). We measured serum CP, ferritin, Fe, high-sensitivity C-reactive protein (hs-CRP), and urinary oxidative stress biomarkers [H2O2, 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-isoprostane] and so on. Subjects showed that age; 41.7 +/- 10.0 (year), CP; 31.9 +/- 6.8 (mg/di), ferritin; 123.5 +/- 121.0 (ng/ml), hs-CRP; 0.89 +/- 2.53 (mg/l), 8-OHdG; 10.2 +/- 4.4 [ng/mg creatinine (Cre)] and H2O2; 6.5 +/- 10.9 (mu M/g Cre), (All data mentioned above were expressed as mean +/- SD). CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG. By a multiple logistic regression analysis, odds ratio of CP according to quartiles of hsCRP was 4.86, and according to quartiles of 8-OHdG was 0.39 after adjusting for age and other confounding factors. In conclusion, our findings suggest that CP was an antioxidative biomarker which controls oxidative stress, whereas ferritin was a marker which may participate in the generation of oxidative stress.
机译:血清铜蓝蛋白(CP)是与铜代谢有关的标志物,是著名的炎症标志物之一,可降低威尔逊氏病,而血清铁蛋白是与铁代谢有关的标志物。最近,指出铁蛋白与氧化应激有关。然而,仍然没有人群研究表明CP和铁蛋白的关系。因此,我们调查了健康日本人(n = 389)中CP和铁蛋白(包括氧化应激生物标记物)之间的关系。我们测量了血清CP,铁蛋白,铁,高敏C反应蛋白(hs-CRP)和尿液氧化应激生物标志物[H2O2、8-羟基-2'-脱氧鸟苷(8-OHdG),8-异前列腺素]等上。受试者表明年龄。 41.7 +/- 10.0(年),CP;铁蛋白31.9 +/- 6.8(mg / di); 123.5 +/- 121.0(ng / ml),高敏C反应蛋白; 0.89 +/- 2.53(毫克/升),8-OHdG; 10.2 +/- 4.4 [ng / mg肌酐(Cre)]和H2O2; 6.5 +/- 10.9(μM/ g Cre),(上述所有数据均表示为平均值+/- SD)。 CP与hs-CRP呈显着正相关,与铁蛋白,Fe和8-OHdG呈负相关。通过多元逻辑回归分析,在校正年龄和其他混杂因素后,根据hsCRP四分位数的CP优势比为4.86,根据8-OHdG四分位数的CP优势比为0.39。总之,我们的发现表明,CP是控制氧化应激的抗氧化生物标记,而铁蛋白是可能参与氧化应激产生的标记。

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