Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: a double-blind, randomized study

摘要

Study objective: Opioids are associated with hyperalgesia that can reduce their analgesic effect. The aim of this study was to determine whether the addition of ketamine reduces remifentanil-induced hyperalgesia; improves its analgesic effect; and alters interleukin 6 (IL-6), IL-8, and IL-10 levels.