Advanced Hepatocellular Carcinoma: Perfusion Computed Tomography-Based Kinetic Parameter as a Prognostic Biomarker for Prediction of Patient Survival

Lee Sang Ho; Hayano Koichi; Zhu Andrew X.; Sahani Dushyant V.; Yoshida Hiroyuki

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Advanced Hepatocellular Carcinoma: Perfusion Computed Tomography-Based Kinetic Parameter as a Prognostic Biomarker for Prediction of Patient Survival

机译：晚期肝细胞癌：灌注计算机断层扫描基于动力学参数作为预测患者生存率的预后生物标志物。

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摘要

Objective The aim of this study was to find prognostic biomarkers in perfusion computed tomography (PCT)-based kinetic parameters for advanced hepatocellular carcinoma (HCC) treated with antiangiogenic chemotherapy.

机译：目的本研究的目的是在基于灌注计算机断层扫描（PCT）的动力学参数中寻找抗血管生成化学疗法治疗的晚期肝细胞癌（HCC）的预后生物标志物。

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《Journal of computer assisted tomography》 |2015年第5期|共10页
作者
Lee Sang Ho; Hayano Koichi; Zhu Andrew X.; Sahani Dushyant V.; Yoshida Hiroyuki;
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正文语种 eng
中图分类放射医学;
关键词
antiangiogenic chemotherapy; hepatocellular carcinoma; imaging biomarker; perfusion CT; TK - Tofts-Kety; 2CX-2-compartment exchange; AATH - adiabatic approximation to the tissue homogeneity; DP - distributed parameter; AIF - arterial input function; BF - blood flow; BV - blood volume; MTT - mean transit time; PS - permeability-surface area product; v(I) - fractional interstitial volume; E- extraction fraction;

机译：抗血管生成化学疗法;肝细胞癌;影像学生物标志物;灌注CT;TK-Tofts-Kety;2CX-2-室交换;AATH-组织均匀性的绝热近似;DP-分布参数;AIF-动脉输入功能;BF-血流BV-血容量;MTT-平均通过时间;PS-通透性表面积积;v（I）-间隙体积分数;E-提取分数;

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1. Advanced Hepatocellular Carcinoma: Perfusion Computed Tomography-Based Kinetic Parameter as a Prognostic Biomarker for Prediction of Patient Survival [J] . Lee Sang Ho, Hayano Koichi, Zhu Andrew X., Journal of computer assisted tomography . 2015,第5期

机译：晚期肝细胞癌：灌注计算机断层扫描基于动力学参数作为预测患者生存率的预后生物标志物。
2. RAF1 expression is correlated with HAF, a parameter of liver computed tomographic perfusion, and may predict the early therapeutic response to sorafenib in advanced hepatocellular carcinoma patients [J] . Ninzi Tian, Dong Wu, Ming Tang, Open medicine . 2020,第1期

机译：RAF1表达与HAF相关，肝脏计算断层灌注的参数，并且可以预测高级肝细胞癌患者中索拉非尼的早期治疗反应
3. 54 POSTER Changes in computed tomography perfusion scan parameters and circulating endothelial cells following bevacizumab administration in patients with advanced hepatocellular carcinoma [J] . A.Zhu, N.Holalkere, A.Norden-Zfoni, European Journal of Cancer Supplements . 2006,第12期

机译：54 POSTER晚期肝细胞癌患者服用贝伐单抗后计算机断层扫描灌注成像参数和循环内皮细胞的变化
4. Kinetic Textural Biomarker for Predicting Survival of Patients with Advanced Hepatocellular Carcinoma After Antiangiogenic Therapy by Use of Baseline First-Pass Perfusion CT [C] . Sang Ho Lee, Koichi Hayano, Dushyant V. Sahani, International conference on medical image computing and computer-assisted intervention;International workshop on abdominal imaging: computational and clinical applications . 2014

机译：动力学纹理生物标志物通过基线首过灌注CT预测抗血管生成治疗后晚期肝细胞癌患者的生存率
5. An exploratory study for the discovery of non-invasive hepatocellular carcinoma biomarkers among high-risk hepatitis C virus infected patients. [D] . Abdalla, Moemen. 2009

机译：在高危丙型肝炎病毒感染患者中发现非侵入性肝细胞癌生物标志物的探索性研究。
6. Water-Exchange-Modified Kinetic Parameters from Dynamic Contrast-Enhanced MRI as Prognostic Biomarkers of Survival in Advanced Hepatocellular Carcinoma Treated with Antiangiogenic Monotherapy [O] . Sang Ho Lee, Koichi Hayano, Andrew X. Zhu, -1

机译：动态对比增强MRI的水交换修饰动力学参数作为抗血管生成单一疗法治疗晚期肝细胞癌生存的预后生物标志物
7. Water-Exchange-Modified Kinetic Parameters from Dynamic Contrast-Enhanced MRI as Prognostic Biomarkers of Survival in Advanced Hepatocellular Carcinoma Treated with Antiangiogenic Monotherapy. [O] . Sang Ho Lee, Koichi Hayano, Andrew X Zhu, 2015

机译：动态对比增强mRI的水交换修正动力学参数作为抗血管生成单药治疗晚期肝细胞癌生存的预后生物标志物。

Advanced Hepatocellular Carcinoma: Perfusion Computed Tomography-Based Kinetic Parameter as a Prognostic Biomarker for Prediction of Patient Survival

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