Polyfunctional Analysis of Human Cytomegalovirus (HCMV)-Specific CD4(+) and CD8(+) Memory T-Cells in HCMV-Seropositive Healthy Subjects Following Different Stimuli

摘要

Following primary human cytomegalovirus (HCMV) infection, both humoral and T-cell-mediated immune responses develop in immunocompetent subjects. However, while antibodies may be measured by different methodologies, the T-cell-mediated response remains to be analyzed in its polyfunctional aspects, in view of defining (following different stimuli) the optimal assay to monitor the HCMV-specific T-cell response in HCMV-seropositive subjects.