Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence

Toiyama Yuji; Tanaka Koji; Kitajima Takahito; Shimura Tadanobu; Kawamura Mikio; Kawamoto Aya; Okugawa Yoshinaga; Saigusa Susumu; Hiro Junichiro; Inoue Yasuhiro; Mohri Yasuhiko; Goel Ajay; Kusunoki Masato

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Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence

机译：升高的血清血管生成素样蛋白2与结直肠癌的转移特性相关：早期诊断和复发的血清生物标志物。

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Purpose: Angiopoietin-like protein 2 (ANGPTL2) is a mediator of chronic inflammation and inflammatory carcinogenesis. The biologic and clinical significance of ANGPTL2 remains unknown in human cancer. Therefore, we investigated the function of ANGPTL2 and evaluated its clinical significance in both primary tumors and matched sera in patients with colorectal cancer.

机译：目的：血管生成素样蛋白2（ANGPTL2）是慢性炎症和炎症性致癌的介质。 ANGPTL2的生物学和临床意义在人类癌症中仍然未知。因此，我们调查了ANGPTL2的功能，并评估了其在大肠癌患者的原发肿瘤和匹配血清中的临床意义。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2014年第23期|共12页
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Toiyama Yuji; Tanaka Koji; Kitajima Takahito; Shimura Tadanobu; Kawamura Mikio; Kawamoto Aya; Okugawa Yoshinaga; Saigusa Susumu; Hiro Junichiro; Inoue Yasuhiro; Mohri Yasuhiko; Goel Ajay; Kusunoki Masato;
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正文语种 eng
中图分类肿瘤学;
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1. Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence [J] . Toiyama Yuji, Tanaka Koji, Kitajima Takahito, Clinical cancer research: an official journal of the American Association for Cancer Research . 2014,第23期

机译：升高的血清血管生成素样蛋白2与结直肠癌的转移特性相关：早期诊断和复发的血清生物标志物。
2. Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer [J] . Vocka M., Langer D., Petrtyl J., Neoplasma: Journal of Experimental and Clinical Oncology . 2015,第3期

机译：三叶因子家族（TFF）蛋白作为转移性结直肠癌患者潜在的血清生物标志物
3. Elevated serum matrix metalloproteinase-3 and -7 in H. pylori-related gastric cancer can be biomarkers correlating with a poor survival. [J] . Yeh YC, Sheu BS, Cheng HC, Digestive Diseases and Sciences . 2010,第6期

机译：幽门螺杆菌相关胃癌中血清基质金属蛋白酶3和-7升高可能是与不良生存相关的生物标志物。
4. An in vivo metabolic labeling approach for the early detection of colorectal cancer protein biomarkers in mouse serum [C] . Melanie M. Ivancic, Edward L. Huttlin, Kelli G. Kline, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：鼠标血清中直肠癌蛋白生物标志物早期检测的体内代谢标记方法
5. CREATINE KINASE ISOENZYMES IN SERUM. A. IN VITRO STUDIES WITH RAT CK-1 AND HUMAN SERUM. B. APPARENT MITOCHONDRIAL CREATINE KINASE IN THE SERUM OF A PATIENT WITH METASTATIC CANCER TO THE LIVER [D] . HEINZ, JOHN WALTER. 1981

机译：血清中的肌酐激酶同工酶。 A.大鼠CK-1和人血清的体外研究。 B.肝转移癌患者血清中的线粒体肌氨酸激酶
6. Excessive collagen turnover products are released during colorectal cancer progression and elevated in serum from metastatic colorectal cancer patients [O] . S. N. Kehlet, R. Sanz-Pamplona, S. Brix, -1

机译：大肠癌发展过程中释放出过多的胶原蛋白转换产物转移性大肠癌患者血清中的胶原蛋白代谢产物升高
7. Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence [O] . Yuji Toiyama, Koji Tanaka, Takahito Kitajima, 2014

机译：血清血管血管素样蛋白2升高与结直肠癌的转移特性相关：血清生物标志物，用于早期诊断和复发

Elevated Serum Angiopoietin-like Protein 2 Correlates with the Metastatic Properties of Colorectal Cancer: A Serum Biomarker for Early Diagnosis and Recurrence

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