ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer

Gao Shuai; Ye Huihui; Gerrin Sean; Wang Hongyun; Sharma Ankur; Chen Sen; Patnaik Akash; Sowalsky Adam G.; Voznesensky Olga; Han Wanting; Yu Ziyang; Mostaghel Elahe A.; Nelson Peter S.; Taplin Mary-Ellen; Balk Steven P.; Cai Changmeng

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ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer

机译：ErbB2信号增加耐阿比特龙的前列腺癌中雄激素受体的表达

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Purpose: ErbB2 signaling appears to be increased and may enhance androgen receptor (AR) activity in a subset of patients with castration-resistant prostate cancer (CRPC), but agents targeting ErbB2 have not been effective. This study was undertaken to assess ErbB2 activity in abiraterone-resistant prostate cancer and to determine whether it may contribute to AR signaling in these tumors.

机译：目的：ErbB2信号似乎在去势抵抗性前列腺癌（CRPC）的部分患者中增加，并可能增强雄激素受体（AR）的活性，但靶向ErbB2的药物却无效。这项研究旨在评估耐阿比特龙的前列腺癌中的ErbB2活性，并确定其是否可能有助于这些肿瘤中的AR信号传导。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第14期|共11页
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Gao Shuai; Ye Huihui; Gerrin Sean; Wang Hongyun; Sharma Ankur; Chen Sen; Patnaik Akash; Sowalsky Adam G.; Voznesensky Olga; Han Wanting; Yu Ziyang; Mostaghel Elahe A.; Nelson Peter S.; Taplin Mary-Ellen; Balk Steven P.; Cai Changmeng;
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正文语种 eng
中图分类肿瘤学;
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1. ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer [J] . Gao Shuai, Ye Huihui, Gerrin Sean, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第14期

机译：ErbB2信号增加耐阿比特龙的前列腺癌中雄激素受体的表达
2. Prostate cancer cells increase androgen sensitivity by increase in nuclear androgen receptor and androgen receptor coactivators; a possible mechanism of hormone-resistance of prostate cancer cells. [J] . Fujimoto N, Miyamoto H, Mizokami A, Cancer investigation . 2007,第1期

机译：前列腺癌细胞通过增加核雄激素受体和雄激素受体共激活因子来增加雄激素敏感性。前列腺癌细胞激素抵抗的可能机制。
3. Dehydroepiandrosterone administration or G{alpha}q overexpression induces {beta}-catenin/T-Cell factor signaling and growth via increasing association of estrogen receptor-{beta}/Dishevelled2 in androgen-independent prostate cancer cells. [J] . Liu X, Arnold JT, Blackman MR Endocrinology . 2010,第4期

机译：脱氢表雄酮给药或Gαq过表达通过增加雄激素非依赖性前列腺癌细胞中雌激素受体-β/ Dishevelled2的缔合而诱导β-连环蛋白/ T细胞因子信号传导和生长。
4. AKT Regulates Androgen Receptor-dependent Growth and PSA Expression in Prostate Cancer [C] . Margarita Mikhailova, Yu Wang, Roble Bedolia, International Symposium on Hormonal Carcinogenesis . 2008

机译：AKT调节前列腺癌中的雄激素受体依赖性生长和PSA表达
5. Co-chaperone influence on androgen receptor signaling and identification of androgen receptor genes in prostate cancer. [D] . Prescott, Jennifer. 2007

机译：伴侣伴侣对前列腺癌中雄激素受体信号传导和雄激素受体基因鉴定的影响。
6. ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer [O] . Shuai Gao, Huihui Ye, Sean Gerrin, -1

机译：ErbB2信号增加耐阿比特龙的前列腺癌中雄激素受体的表达
7. Dehydroepiandrosterone Administration or Gαq Overexpression Induces β-Catenin/T-Cell Factor Signaling and Growth via Increasing Association of Estrogen Receptor-β/Dishevelled2 in Androgen-Independent Prostate Cancer Cells [O] . Liu, Xunxian, Arnold, Julia T., Blackman, Marc R. 2010

机译：脱氢表雄酮给药或Gαq过表达通过增加雄激素非依赖性前列腺癌细胞中雌激素受体β/ Dishevelled2的缔合来诱导β-Catenin/ T细胞因子信号传导和生长。
8. Molecular Determinants of Prostate Cancer Progression Across Race- Ethnicity. Project A - The Human 5RD5A2 Gene and Prostate Cancer Progression. Project B - Androgen Receptor (AR) Signaling in Prostate Cancer Progression. Project C - Cellular and Molecular Markers of Prostate Cancer Progression Core - Epidemiology Core [R] . Ross, R. R. , Reichardt, J. , Coetzee, G. A. , 2002

机译：跨越种族的前列腺癌进展的分子决定因素。项目a - 人类5RD5a2基因和前列腺癌进展。项目B - 雄激素受体（aR）在前列腺癌进展中的信号传导。项目C - 前列腺癌进展核心的细胞和分子标记 - 流行病学核心

ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer

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