A patient with metastatic breast cancer 15 years after bilateral prophylactic total mastectomy and oophorectomy

摘要

The ideal management of patients carriers of the Breast Cancer gene mutation in clinical practice (BRCA)1 or BRCA2 mutations is unknown. Prophylactic mastectomy and oophorectomy reduces the risk of invasive breast cancer in patients with BRCA1 and BRCA2. The risk of invasive breast cancer is not completely eliminated by prophylactic mastectomy and oophorectomy. We report the case of a patient who underwent prophylactic total mastectomy and oophorectomy and presented with metastatic breast cancer 15 years after the surgeries. To our knowledge this is the first case report of metastatic breast cancer presenting after mastectomy and oophorectomy without evidence of a primary tumor and the first case report of carcinomatous meningitis as a presenting sign of metastatic breast cancer after prophylactic mastectomy and oophorectomy.