Enantioselective hydrogenation of ketopantolactone: Effect of stereospecific product crystallization during reaction

摘要

The hydrogenation of ketopantolactone over cinchonidine-modified Pt/alumina has been reinvestigated, focussing on the misleading effect of stereospecific product crystallization during reaction at medium to high conversions. The appropriate choice of reaction conditions afforded 91.6 +/- 0.5% ee to R-(-)-pantolactone. (C) 1998 Academic Press. [References: 5]