Associations of the CYP3A5*3 and CYP3A4*1G polymorphisms with the pharmacokinetics of oral midazolam and the urinary 6-hydroxycortisol/cortisol ratio as markers of CYP3A activity in healthy male Chinese

摘要

What is known and objectiveThe oral plasma clearance of midazolam and the ratio of 6-hydroxycortisol (6-OHF) to cortisol (F) in urine are two potential markers for evaluating CYP3A activity in vivo. We assessed the influence of two common CYP3A polymorphisms on the pharmacokinetics of oral midazolam and urinary ratio of 6-OHF/F in healthy Chinese.