Regression of Chemotherapy-Resistant Polymerase epsilon (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

Santin Alessandro D.; Bellone Stefania; Buza Natalia; Choi Jungmin; Schwartz Peter E.; Schlessinger Joseph; Lifton Richard P.

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Regression of Chemotherapy-Resistant Polymerase epsilon (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

机译：耐化学性聚合酶epsilon（POLE）超突变和MSH6超突变子宫内膜肿瘤与Nivolumab的回归

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Purpose: The management of endometrial carcinoma no longer amenable to treatment with surgery or radiotherapy has not improved significantly with modern chemotherapy. Alternative therapeutic options are desperately needed.

机译：目的：子宫内膜癌的治疗不再适合通过手术或放疗进行治疗，但现代化学疗法并没有明显改善。迫切需要替代疗法。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2016年第23期|共6页
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Santin Alessandro D.; Bellone Stefania; Buza Natalia; Choi Jungmin; Schwartz Peter E.; Schlessinger Joseph; Lifton Richard P.;
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正文语种 eng
中图分类肿瘤学;
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1. Regression of Chemotherapy-Resistant Polymerase epsilon (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab [J] . Santin Alessandro D., Bellone Stefania, Buza Natalia, Clinical cancer research: an official journal of the American Association for Cancer Research . 2016,第23期

机译：耐化学性聚合酶epsilon（POLE）超突变和MSH6超突变子宫内膜肿瘤与Nivolumab的回归
2. Diagnosis and management of a recurrent polymerase-epsilon (POLE)-mutated endometrial cancer [J] . Veneris Jennifer Taylor, Lee Elizabeth K., Goebel Emily A., Gynecologic Oncology: An International Journal . 2019,第3期

机译：复发聚合酶 - ε-ε-审查子宫内膜癌的诊断和管理
3. Polymerase epsilon (POLE) Mutations in Endometrial Cancer: Clinical Outcomes and Implications for Lynch Syndrome Testing [J] . Billingsley Caroline C., Cohn David E., Mutch David G., Cancer: A Journal of the American Cancer Society . 2015,第3期

机译：子宫内膜癌中的聚合酶ε（POLE）突变：临床结果和对林奇综合症的启示
4. Regression of chemotherapy-resistant Polymerase ε (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab [O] . Alessandro D. Santin, Stefania Bellone, Natalia Buza, -1

机译：尼古鲁单抗使化疗耐药的聚合酶ε（POLE）超突变和MSH6超突变子宫内膜肿瘤消退
5. Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles [O] . Iliana Siamishi, Norimasa Iwanami, Thomas Clapes, 2020

机译：DNA聚合酶ε的淋巴细胞特异性偶像亚单位柱3揭示了新立体等位基因

Regression of Chemotherapy-Resistant Polymerase epsilon (POLE) Ultra-Mutated and MSH6 Hyper-Mutated Endometrial Tumors with Nivolumab

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