Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging

摘要

This study was designed to quantitatively analyse neovascular permeability in glioma by dynamic contrast-enhanced MRI (DCE-MRI). Forty-four patients with glioma were included in this study. The highest value of volume transfer constant (K trans) and volume of extravascular extracellular space per unit volume of tissue (V e) were obtained and the differences in K trans and V e between low-grade glioma (LGG) and high-grade glioma (HGG) were analyzed. The correlations between K trans, V e and glioma grade were performed. Receiver operating characteristic (ROC) curve analyses were conducted. The values of K trans and V e of LGG were significantly lower than those of HGG. The correlation analysis demonstrated statistically significant relationships between K trans and glioma grade, between V e and glioma grade, and between K trans and V e. The ROC curve analyses of K trans (0.035/min) and V e (0.130) for differentiating LGG from HGG were statistically significant. Thus, DCE-MRI can be used to estimate neovascular permeability and for pre-operative grading of glioma.