Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins.

Kwon BM; Kim MK; Baek NI; Kim DS; Park JD; Kim YK; Lee HK; Kim SI

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Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins.

机译：酰基辅酶A：由人参皂苷产生的人参皂苷元的胆固醇酰基转移酶抑制活性。

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Ginseng sapogenins were produced from ginseng saponins, isolated from Korean ginseng roots. Ginseng saponins very mildly inhibited acyl-CoA:cholesterol acyltransferase (ACAT) in vitro, however, the sapogenins showed strong inhibitory activity on microsomal ACAT. Therefore, the sapogenins will be one of key ingredients of ginseng affected a lowering of the serum total cholesterol level.

机译：人参皂甙元是从人参皂甙中提取的，人参皂甙是从韩国人参根中分离出来的。人参皂苷在体外非常轻微地抑制了酰基辅酶A：胆固醇酰基转移酶（ACAT），但是，皂甙元对微粒体ACAT表现出强大的抑制活性。因此，皂甙元将是人参的关键成分之一，影响人血清总胆固醇水平的降低。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |1999年第10期|共4页
作者
Kwon BM; Kim MK; Baek NI; Kim DS; Park JD; Kim YK; Lee HK; Kim SI;
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正文语种 eng
中图分类药学;生物化学;
关键词
Enzyme Inhibitors; Ginseng; Sapogenins; Saponins; Sterol O Acyltransferase antagonists and inhibitors; 酶抑制剂; 人参; 皂角苷配基; 皂苷类;

机译：Enzyme Inhibitors;Ginseng;Sapogenins;Saponins;Sterol O Acyltransferase antagonists and inhibitors;酶抑制剂;人参;皂角苷配基;皂苷类;

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1. Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins. [J] . Kwon BM, Kim MK, Baek NI, Bioorganic and Medicinal Chemistry Letters . 1999,第10期

机译：酰基辅酶A：由人参皂苷产生的人参皂苷元的胆固醇酰基转移酶抑制活性。
2. Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation [J] . Chemical and Pharmaceutical Bulletin . 2010,第8期

机译：具有抑制酰基辅酶A活性的新型四氢异喹啉衍生物：胆固醇酰基转移酶和脂质过氧化
3. Human Acyl-CoA:Cholesterol Acyltransferase(hACAT)Inhibitory Activities of Triterpenoids from Roots of Glycine max(L.)Merr. [J] . Jin Hwan Lee, Young Bae Ryu, Byong Won Lee Bulletin of the Korean Chemical Society . 2008,第3期

机译：人酰基辅酶A：胆固醇酰基转移酶（hACAT）对大豆根中三萜类化合物的抑制作用
4. Comparison of Antioxidant Activity Ginseng (Panax Ginseng CA Meyer) Root Extraction between Ultrasound and Microwave Processing [C] . Chengwen Lu, Yongguang Yin International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences . 2018

机译：抗氧化活性人参（Panax人参CA Meyer）超声和微波加工之间的根提取
5. Mouse acyl-CoA binding protein: Effect on acyl-CoA utilization by microsomal acyl-CoA:cholesterol acyltransferase and membrane interactions. [D] . Chao, Hsu. 2002

机译：小鼠酰基辅酶A结合蛋白：微粒体酰基辅酶A：胆固醇酰基转移酶和膜相互作用对酰基辅酶A利用的影响。
6. Inhibitory effect of red ginseng acidic polysaccharide from Korean red ginseng on phagocytic activity and intracellular replication of Brucella abortus in RAW 264.7 cells [O] . Alisha Wehdnesday Bernardo Reyes, Hannah Leah Tadeja Simborio, Huynh Tan Hop, 2016

机译：红参红参酸性多糖对RAW 264.7细胞吞噬布鲁氏菌的吞噬活性和细胞内复制的抑制作用
7. Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation [O] . Masaru Ohta, Kenji Takahashi, Masayasu Kasai, 2010

机译：具有抑制作用对酰基 - CoA的抑制活性的新型四氢异喹啉衍生物：胆固醇酰基转移酶和脂质过氧化

Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins.

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