Chromatographic approach to study #beta#-cyclodextrin as a promoter of the penetration of bifonazole into keratinic tissue

摘要

A high-performance liquid chromatographic method for the determination of bifonazole in dimethyl sulfoxide solvent was developed to study its penetration into sheephoof. The analytical method was linear over the concentration range studied,i.e.,from 0.1 mg/ml to 1 mg/ml. The relative standard deviation was less than 2%. The data obtained showed that complex forming with #beta#-cyclodextrin greatly improved the penetration of bifonazole.