Global standardisation of haemoglobin A 1c using metrological principles

摘要

Following the publication of the Diabetes Control and Complications Trial (DCCT) study in 1993 [1] the issue of international standardisation of glycated haemoglobin (GHb) measurements became an important objective for scientists and clinicians. The lack of international standardisation resulted in several countries developing national standardisation programmes. The most widely recognised is the National Glycohemoglobin Standardization Program (NGSP) [2]; this programme utilises a high performance liquid chromatography (HPLC) system as described by Goldstein et al. in 1984 [3], and this is used as an anchor to which secondary reference laboratories (SRLs) are standardised. These SRLs are then used to standardise clinical methods.