Alterations in cyclic GMP levels in preeclampsia may reflect increased B-type natriuretic peptide levels and not impaired nitric oxide activity.

摘要

OBJECTIVES: We compared nitrite, B-type natriuretic peptide (BNP), and cGMP levels in preeclamptic with those found in healthy pregnant. METHODS: We studied 21 healthy pregnant and 27 preeclamptic. Plasma cGMP and BNP levels were determined by ELISA. Nitrite levels were determined by chemiluminescence. RESULTS: Higher cGMP and BNP, and lower nitrite levels were found in preeclamptic versus healthy pregnant. CONCLUSIONS: Altered cGMP levels reflect increased BNP levels and not impaired nitric oxide activity in preeclampsia.