Metal template effect on O-alkylation of tetrathiacalix[ 4 ]arene with 2-bromoacetamide to afford tetrakis(carbamoylmethoxy)thiacalix [4]arenes with cone and 1,3-alternate conformation

摘要

Direct O-alkylation of tetrathiacalix[41arene with 2-bromoacetamide afforded two conformational isomers (cone and 1.3-alternate) of tetrakis(carbamoylmethoxy)thiacalix[ 41arene and 1.3-disubstituted bis(carbamoylmethoxy)thiacalix [41arene. depending on the base used.