An efficient one-pot synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles under solvent-free conditions

摘要

An efficient and simple synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with alkyl 2,2-dialkoxyacetates under solvent-free conditions to produce the title compounds in excellent yields.