Synthesis of alkyl 2[2-oxopyridin-1(2H)-yl]acrylates by nucleophilicaddition of alkyl propiolates catalysed by Ph3P

摘要

2-Hydroxypyridine undergoes a smooth reaction with alkyl propiolates in the presence of triphenylphosphine(15 mol%) to produce the corresponding alkyl 2-12-oxopyridin-1(2H)-yl]acrylates in good yields. When the reaction wasperformed by 2-hydroxyquinoline and 2-hydroxyisoquinoline similar a-substituted alkyl acrylates were obtained.