Copper-catalysed couplings of N-substituted-N-methacryloylbenzamides with isopropanol to generate hydroxyl-substituted isoquinoline-1,3(2H,4H)-dione derivatives

摘要

A copper-catalysed free-radical cascade cyclisation of N-substituted-N-methacryloylbenzamides with isopropanol has been developed, which allows convenient access to various hydroxyl-substituted isoquinoline-1,3(2H, 4H)-dione derivatives.