Facile and efficient one-pot synthesis of highly functionalised 1,2,3,5-tetrahydroimidazo[1,2-a] pyrimidines

摘要

The one-pot, three-component reaction between isocyanides, electron-deficient acetylenic esters and 2-amino-1-methyl-1H-imidazol4(5H)-one efficiently leads to highly functionalised 1,2,3,5-tetrahydroimidazo[1,2-a] pyrimidines without any activation in excellent yields at room temperature.