A green, facile approach for the multicomponent synthesis of bioactive spiro[indoline-3,7 '-pyrrolo[1,2-c]imidazole] derivatives

摘要

An efficient synthesis of spiro[indoline-3,7'-pyrrolo[1,2-c]imidazole] is achieved through a three-component reaction of isatins, malononitrile, and hydantoin/2-thiohydantoin in water catalysed by NaHCO3. All the target compounds were screened for the Cell Division Cycle 25 Phosphatase B (CDC25B) inhibitory activities.