Indole-benzodiazepine-2,5-dione derivatives from Neosartorya fischeri

摘要

One new aszonalenin analogue, 6-hydroxyaszonalenin was isolated from the culture of Neosartorya fischeri CGMCC 3.5378, together with aszonalenin, acetylaszonalenin, fumitremorgin B, verruculogen, and aszonapyrones A and B. The structure of the new metabolite was elucidated by comprehensive spectroscopic analyses, especially HR-ESI-MS and NMR experiments. The absolute configuration of 6-hydroxyaszonalenin was determined by X-ray diffraction. To the best of our knowledge, aszonapyrone B was reported for the first time from this species.