Microwave-enhanced catalyst-free aminolysis of epoxides with anilines in aqueous phase: Efficient synthesis of β-amino secondary alcohols

摘要

β-Amino secondary alcohols were formed by aminolysis of epichlorohydrin and styrene oxide with aromatic amines using aqueous ethanol (1:1) as the solvent in conjunction with microwave irradiation without a catalyst. The methodology is fast, efficient, highly regioselective, chemoselective and environmentally benign.