Lewis base-catalysed Mukaiyama-aldol reaction of trimethylsilyl enolates with aldehydes

摘要

An efficient Mukaiyama-type aldol reaction of three typical silyl enolates, such as 1-(trimethylsiloxy)-1-methoxy-2-methyl-2-propene, 1-phenyl-1- trimethylsilyloxyethene and 1, 2-bis(trimethylsiloxy)cyclobutene, with aryl aldehydes and a,β-unsaturated aldehydes catalysed by 5 mol% of Lewis base catalyst 4-O_2NPhOMgI in dichloromethane is described. The reaction proceeds under mild reaction conditions in good to excellent yields.