Four-component reaction between cyclohexyl isocyanide, aromatic aldehydes, aromatic amines and trifluoroacetic anhydride

摘要

Reaction of cyclohexyl isocyanide with aromatic aldehydes, aniline derivatives and trifluoroacetic anhydride in dichloromethane at room temperature afforded N-[cyclohexylcarbamoyl(aryl)methyl]-2,2,2-trifluoro-N-arylacetamide derivatives in nearly quantitative yields after 10 min. The work-up procedure is very easy and the products are precipitated in ether as pure solids. The structure of one of the products was established by X-ray single crystal analysis.