Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2007

摘要

This is the eleventh installment of the comprehensive survey series in combinatorial chemistry. This year there is a new grouping highlighting molecular probes (Table 6) and a separate inventory of fluorous technology (Table 13). Bioactive libraries are captured in Tables 1—5 under the headings of proteases, nonproteolytic enzymes, GPCRs, nonGPCRs, and oncolytics/antiinfectives. Compound collections without disclosed biological activity are captured in Tables 7—10 under the headings of scaffold derivatization/ acyclic synthesis, monocyclic, bicyclic/spirocyclic, and poly-cyclic/macrocyclic synthesis. Polymer-supported reagents/ scavengers/linkers and polymer-supported chiral ligands are presented in Tables 11 and 12, respectively. There are a total of 498 entries this year.