Iron Carbonyl-Mediated Parallel Solution-Phase Synthesis of Cyclohexadienoic Acid Amides

摘要

Iron carbonyl-stabilized cations have been employed to develop methodology for carbon-carbon and carbon-heteroatom formation suitable for the preparation of combinatorial libraries.Different nucleophiles were added to tricarbonyl(cyclohexa-l,3-dienylcarboxylic acid 4-nitro-phenyl ester)iron hexafluorophosphate.Aminolysis,followed by decomplexation,yielded substituted cyclohexadienyl amides of high purity.Carbon,oxygen,and sulfur nucleophiles gave good results,while amine nucleophiles gave products of somewhat lower purity.