Automated Flow-Through Synthesis of Heterocyclic Thioethers

摘要

The fully automated,sequential flow-through synthesis of a 44-member array of thioethers 10{1-4,1-11} employing a resin "capture and release" reactor column is described.The array incorporates four different heterocyclic scaffolds,and the synthesis was performed using a custom-built robotic synthesizer that is able to (i) load and regenerate the reactor column and (ii) array each product into a single vial using UV threshold detection.All the compounds were obtained in high yield (>75%) and excellent purity (>95%) without the need for further purification.