Synthesis and cytotoxicity of pyrrole-amino acid dipeptides containing phosphonyl group

摘要

A series of pyrrole-amino acid dipeptide were synthesised by chloroform reaction and coupling reaction using DCC/HOBT as promoting additives. The structure of compound was confirmed by H-1 NMR, P-31 NMR, MS and IR. The biological activity data showed that the dipeptide containing nitrogen mustard group inhibited all four cells that were examined.