Parallel Solution-Phase Synthesis of 2-Alkylthio-5-arylidene-3,5-dihydro-4H-imidazol-4-one by One-Pot Three-Component Domino Reaction

摘要

A practical protocol for the preparation of a parallel solution-phase library of 5-arylidene imidazolone is reported.Target compounds were obtained in good yield,stereoselectively,and purity by one-pot domino reaction from various thiohydantoines,arylaldimines,and halogenoalkanes.Purification of the final products by recrystallization with a mixture of pentane/ethanol allowed simple isolation of the 17 components of the array.