Large Uniform-Sized Polymer Beads for Use as Solid-Phase Supports Prepared by Ascension Polymerization

摘要

Large uniform-sized polymer beads are desirable for "one-bead-one-compound" applications in the combinatorial synthesis of compound libraries.We have developed a technique for the preparation of large polymer spheres with narrow size distributions.Uniform-sized poly(styrene-co-divinylbenzene)beads with diameters in excess of 1 mm have been prepared by free radical polymerization in an ascension process through a heated column.The size of the beads can be adjusted by the diameter of the injection needle and the injection speed.The resin beads can be made porous by the incorporation of a porogen during the preparation;they reach a specific surface area in excess of 200 m~2/g.The mechanical properties of the spheres and their use in organic synthesis have been studied.