Effect of second and third generation oral contraceptives on C-reactive protein, lipids and apolipoproteins in young, non-obese, non-smoking apparently healthy women.

摘要

OBJECTIVE: Third generation oral contraceptives (OC) may increase the risk of cardiovascular events in healthy young women. DESIGN AND METHODS: We assessed the effect of second and third generation OC on CRP, lipids and apolipoproteins in 128 women. RESULTS: CRP was significantly higher in third generation contraceptive users. The main determinant of CRP in OC users was triglycerides. CONCLUSIONS: Young women using oral contraceptives, especially third generation formulas, might not be free of cardiovascular risk having increased CRP concentration.