The metal template effect on O-alkylation of hexahomotrioxacalix[3]arene with 4-(chloromethyl)pyridine to afford tris[(4-pyridylm ethyl)oxy]hexahomotrioxacalix[3]arenes and their conformational studies

摘要

O-Alkylation of the flexible macrocycle 1 with 4-(chloromethyl)pyridine gave di- and tri-O-alkylated products with cone or partial-cone conformation which ratio was affected by NaH or alkali metal carbonates used as a base. [References: 12]