The 1,3-dipolar cycloaddition reaction of 7,14-dioxa-1-azadispiro[4.2.5.2]pentadec-1-ene 1-oxide derivatives with N-phenylmaleimide. An attempt to synthesize azasugar analogues of showdomycine

摘要

7,14-Dioxa-1-azadispiro [4.2.5.2]pentadec-1-ene-1-oxide derivatives (1) undergo 1,3-dipolar cycloaddition reaction with N-phenylmaleimide (2) giving the corresponding isoxazolidines (3); attempts to convert 3 into the showdomycine azasugar analogues A and B failed. [References: 8]