Increased urinary cystatin C reflects structural and functional renal tubular impairment independent of glomerular filtration rate.

摘要

OBJECTIVES: The ratio of the urinary mass concentrations of cystatin C and creatinine (UcysC/Ucrea)>/=11.3 mg/mmol has recently been proposed as an accurate marker for the detection of GFR/=11.3 mg/mmol and factors associated with increased UcysC/Ucrea in 72 children and adults with a wide variety of renal disorders. UcysC/Ucrea was calculated, and GFR wad estimated from serum creatinine and cystatin C by equations. RESULTS: UcysC/Ucrea>/=11.3 mg/mmol had a low diagnostic value to detect GFR values/=11.3 mg/mmol is not an accurate marker to detect GFR