Pathogenesis from the reactivation of chromosomally integrated human herpesvirus type 6: Facts rather than fiction

摘要

Viral latency, defined by the ability of a virus to remain dormant, is a commonly used immune evasion strategy that enables the long-term persistence of viruses within the infected host. On occasion, these viruses come out of latency and initiate their replicative cycles, yielding a progeny of infectious virions favoring viral propagation and dissemination with possible pathogenic outcomes depending on the immunological competency of the host. Among the most successful viruses utilizing latency as a mean of persistence are herpesviruses.