Concordance between measures of functioning, symptoms, and change: examining the GAF, CGI-S, CGI-C, and PANSS.

摘要

The clinical implications of the Positive and Negative Syndrome Scale (PANSS) are sometimes not readily apparent. To give clinical meaning to PANSS ratings, past research has linked scores on the Clinical Global Impression of Severity (CGI-S) and change (CGI-C), both of which are single-item 7-point ratings, with the 30-item PANSS. Those studies have shown, for example, that a CGI-S rating of "mildly ill" corresponds to a PANSS total score of approximately 58 and that a CGI-C rating of "minimal improvement" corresponds to a 19% PANSS total reduction. This study aimed to (a) replicate the CGI and PANSS linkage, (b) elaborate by examining linkage between PANSS scores and the Global Assessment of Functioning (GAF) scale, and (c) examine the correspondence of a 20% change on the PANSS total (ie, treatment response) with the other measures.