The shifting dynamics of pneumococcal invasive disease after the introduction of the pneumococcal 7-valent conjugated vaccine: toward the new pneumococcal conjugated vaccines.

摘要

Since the introduction of the first pneu-mococcal conjugated vaccine, the 7-valent conjugated vaccine (PCV7), a tremendous reduction in the incidence of invasive pneumococcal disease (IPD) has been observed in all countries having introduced its use [1-3]. That reduction, mainly of the serotypes included in the vaccine, has been directly observed in vaccinated children [1]. The rate of hospitalization for Streptococcus pneumoniae meningitis reported by Tsai et al. [4] decreased by 66.0% and 51.5% among children aged <2 and 2-4 years, respectively. The incidence of other S. pneumoniae-rehXed diseases, such as community-acquired pneumonia and acute otitis media, also decreased among young children after PCV7 introduction [5, 6].