Measuring Tablet Dissolution: An Experiment for Teaching Quantitative Ultraviolet Absorption Spectroscopy

摘要

Dissolution testing is a quantitative analytical technique used to measure the release rate of ingredients from tablets and capsules. This instrumental analysis lab experiment teaches students how to compress tablets from a mixture of powders and challenges students to build their own apparatus to measure dissolution rates of their tablets. Each group of students was able to complete the experiment successfully and elucidate two predicted trends in dissolution rates from a set of five tablets. Students learned the fundamentals of UV spectroscopy, data handling, calibration, and sampling, while gaining insight and experience regarding an important test used in the pharmaceutical and dietary supplement industries.