Synthesis and crystal structures of 2-amino-3-cyano-4(2-chlorophenyl)-1,4-dihydro-2H-pyrano[3, 2-h] quinoline and 2-amino-3-cyano-4-(2-chlorophenyl)-8(2-chlorobenzylidene)-1,4,5,6,7,8-hexa hydrobenzo[b]pyran

摘要

The title compounds 2-amino-3-cyano-4-(2-chlorophenyl)-1,4-dihydro-2H-pyrano[3, 2-h]quinoline 1 (C19H12ClN3O, M-r = 333.77) and 2-amino-3-cyano-4-(2-chlorophenyl)-8-(2-chlorobenzylidene)-1,4,5,6,7,8-hex ahydrobenzo[b]pyran 2 were synthesized and crystallized. The crystals of compound 1 are triclinic, space group P-1, a = 7.488( 2), b = 9.127(3), c = 12.252(3) Angstrom, alpha = 73.58(2), beta = 78.38(2)degrees, gamma = 75.39(2), Z = 2, V = 769.5(4) Angstrom(3); The compound 2 crystallizes in space group P2(1), with cell parameters a = 13.582(2), b = 8.974(1), c = 16.960(2) Angstrom, beta = 103.34(1)degrees and D-calc = 1.352 g/cm(-3) for Z = 4. X-ray analysis reveals that atoms C(1)-C(5) and O form a pyran ring in compound 1, which adopts half-chair conformation. In compound 2 the atoms C( 2)-C(16) and O form a pyran ring which adopts boat conformation, another six-membered ring (C(8)-C(13)) adopts a half-chair conformation. In addition, there are intermolecular hydrogen bonds in the crystal structures 1 and 2. [References: 17]