Syntheses and Structures of Substituted [4-(2,2,2-Trifluoroethoxy)-2-Pyridinyl]-Methylthio-Imidazoles and -Pyrimidines

摘要

Reactions of substituted 2-(chloromethyl)-pyridine (1a-1b) and substituted imidazole-2-thione (2a-2c) in the presence of sodium methoxide afforded a series of substituted [4-(2,2,2-trifluoroethoxy)-2-pyridinyl]-methylthio-imidazoles (3a-3f) in good yields. Similar reactions of compounds 1a-1b with different pyrimidine-2-thiol (4a-4b) led to the corresponding [4-(2,2,2-trifluoroethoxy)-2-pyridinyl]-methylthio-pyrimidine (5a-5d, av. 90 %) derivatives. Molecular structures of compounds 3a and 5b were confirmed by single-crystal X-ray diffraction analyses. The unit cells of both compounds have monoclinic P2(1)/c symmetry with