Solubility, Density, and Metastable Zone Width of Pyridoxine Hydrochloride in Water and Ethanol Solvent Mixtures

摘要

The solubility of pyridoxine hydrochloride in water and ethanol solvent mixtures was measured using a laser monitoring observation technique at the temperature range from (278.15 to 323.15) K. The mole fraction of ethanol in the solvent mixtures (x(3)) ranges from 0.0 to 0.6012. For the seven group data studied, the experimental solubility data were well-correlated with the results calculated by means of a semiempirical equation. Densities of pyridoxine hydrochloride in solvent mixtures were investigated at temperatures from (293.15 to 323.15) K. The effects of ethanol mole fraction, cooling rate, and saturation temperature on the metastable zone width (MZW) were also studied. The results show that the MZW of pyridoxine hydrochloride becomes narrower by increasing the saturation temperature, increasing ethanol mole fraction, and reducing the cooling rate. For the density and the MZW, all results were correlated by empirical equations.